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low certainty).40 Pharmacotherapy and combined behavioural and pharmacotherapy interventions Our review showed that bupropion may result in little to no harm, although data were of very low certainty or could not be evaluated for certainty because not enough data were provided.22 An updated Cochrane review on bupropion41 suggested there may be a small increase in adverse events, which could constitute a small harm (Appendix 1 and Appendix 2)